Human Cytogenetics: Malignancy and acquired abnormalities v. 2 A Practical Approach
D Rooney and B Czepulkowski
Paperback: 624 pages
Publisher: Oxford University Press; 3rd Revised edition (28 Jun 2001)
ISBN-10: 0199638438 (sold as a set) ISBN-10: 0199638411 (sold separately)
Human Cytogenetics: Malignancy and acquired abnormalities concentrates on the specialised areas of leukaemia and tumour cytogenetics, as well as chromosome instability syndromes and mutagen induced chromosomes damage studies. Since the publication of the highly successful second edition of this book in 1992, fluorescent in situ hybridisation (FISH) technology has led to enormous advances in this specialised field due to the application of approaches such as comparative genomic hybridisation and multiplex FISH. As such, an exciting new chapter has been introduced to the revised edition, providing protocols for FISH methodologies relevant to the research cytogeneticist and diagnostician alike. Improved methods for the detection of chromosome abnormalities in malignant tissues have led to more accurate diagnosis and prognosis of specific diseases. This is reflected in the thorough updating of all chapters in this new edition. In the current climate of health and safety awareness, the protocols now include information on hazards are safe handling of chemicals and reagents listed. Our goal has been to build on the success of the previous two editions of this volume providing a state of the art laboratory manual. The result is a book that will be invaluable to all scientists involved in cytogenetic study. Along with it’s sister volume Human Cytogenetics: Constitutional analysis, this book will be an essential purchase for all cytogeneticists, both research and diagnostic.